MyBioSource.com's Mouse Anti-TPX2 Antibody is a Mouse monoclonal antibody. The Mouse Anti-TPX2 Antibody was generated using TPX2, and TPX2 microtubule nucleation factor as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
TPX2 is a spindle assembly factor, required for normal assembly of mitotic spindles, for normal assembly of microtubules during apoptosis, and for chromatin and/or kinetochore dependent microtubule nucleation. TPX2 mediates AURKA localization to spindle microtubules, activates AURKA by promoting its autophosphorylation at 'Thr-288', and protects this residue against dephosphorylation